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the FDA declined that reading for the liver cluster 2025 systematic review (HSS Journal): recommends caution due to limited high-quality clinical evidence 2025 narrative review: flags theoretical pathologic angiogenesis risk Stable in gastric acid (oral administration viable) Human side effects reported remain mild, on an uncontrolled record with one underpowered controlled read Foundational reviews Sikiric P, Seiwerth S, et al