This 12 week study with a 40 week extension period revealed that the addition of vildagliptin significantly lowered HbA1c levels by week 12, with the improvement being sustained to the end of the study period, whereas glycaemic control deteriorated in the placebo recipients (34)
In line with evidence from GLP-1RA studies, tirzepatide exhibited a stabilizing effect on UACR, leading to a least square mean difference of 31.9 (95% CI 37.7 to 25.7) mg/g with insulin glargine [49]
Examples of commonly used GLP-1 RAs, approved by regulatory bodies like the UKs MHRA, include: Liraglutide (Brand names: Victoza for diabetes, Saxenda for weight management) Administered as a daily injection
Cell Stem Cell 28 , 331342.e5 (2021)
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