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[7] Whether this chloride flow is depolarizing (makes the voltage across the cell's membrane less negative), shunting (has no effect on the cell's membrane potential), or inhibitory/hyperpolarizing (makes the cell's membrane more negative) depends on the direction of the flow of chloride

Biomed Pharmacother 151:113072 Abulfadl YS, El-Maraghy NN, Ahmed AE, Nofal S, Abdel-Mottaleb Y, Badary OA (2018) Thymoquinone alleviates the experimentally induced Alzheimers disease inflammation by modulation of TLRs signaling

Both findings matter, but they come from different programs, with different timelines and study designs

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