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PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega- O -acylceramide synthesis and skin permeability barrier

3.2 Necroptosis of tubular epithelial cell in DKD Transcriptomic and single-nucleus RNA sequencing analyses have demonstrated significant enrichment and perturbations of the necroptosis pathway in diabetic kidney tissues, highlighting its core role in driving tubulointerstitial injury (27, 135)

Trimethylamine N-Oxide and related gut Microbe-Derived metabolites and incident heart failure development in Community-Based populations