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Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development

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Consequence 2: Nicotinamide salvage interference

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Extremely concentrated solutions (over ~5 mg/mL for most therapeutic peptides) can hit solubility limits and remain cloudy