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262 Infertility is a serious cause of psychological and emotional distress, often prompting reactions such as shock, a sense of losing control, low self-esteem, anger, frustration, sadness, and grief, and the emotional toll increases the longer infertility persists

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Supplementation of cystine suppressed the ISR as evidenced by the reduction of phospho-eIF2 (S51) and ATF4, but rapamycin treatment had no discernible effect (Fig