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The most common adverse reactions reported in clinical trials include gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation), which occurred in a substantial proportion of patients but are generally transient
Researchers discovered that the bodys natural GLP-1 system activates specific brain cells called GABA neurons (gamma-aminobutyric acid) in a region called the ventral tegmental area, or VTA
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Specifically, DPP-4 cleaves the peptide bond between Ala 8 -Glu 9 resulting in the abundant GLP-1 (936) amide constituting 6080% of total GLP-1 in circulation
