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severe thiamine deficiency, while rare, can cause Wernickes encephalopathy in hyperemesis gravidarum, and inadequate B is associated with anemia and neurologic issues in the newborn
Part of the reason for this test no longer being used is that cobalt radioisotopes required are no longer available and also partly because injectable B12 and large dose oral B12 are relatively inexpensive
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The trial concluded that AOD-9604 did not induce significant weight loss, leading to a halt in the development of the drug as a weight-loss solution
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