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After 68 weeks, participants receiving a 2.4 mg weekly semaglutide dose experienced a 49% reduction in C-reactive protein (CRP), while those on a 1 mg weekly dose saw a 42% reduction compared to placebo
Mechanisms identified include: increased cardiac utilization of ketones increased autophagy (recycling of intracellular components)l decreased inflammation & oxidative stress improved mitochondrial function decreased intracellular Ca & Na overload decreased fibrosis improved myocardial diastolic function decrease myocardial hypertrophy Figure 1
Cells 11 , 2587 (2022)
operations, stated in The Wall Street Journal: We now have injectable-like efficacy in a once-daily pill
Patients who have been off treatment for several weeks may experience renewed or intensified side effects when resuming at their previous maintenance dose, particularly nausea and abdominal discomfort
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