The primary comparisons evaluated were: DPP-4 inhibitors served as the reference group because, while sharing a common indication (T2DM), they are thought to have lesser neuroprotective effects than the other two classes
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Unlike older medications such as phentermine or orlistatwhich suppress appetite via the central nervous system or block dietary fat absorptionsemaglutide enhances feelings of fullness and reduces hunger, helping our patients decrease their calorie intake more effectively
It was very obvious from very early on that targeting one pathological process is not going to be enough, Paul Edison, MBBS, PhD, a professor of neuroscience at Imperial College London, told Verywell
A systematic review and meta-analysis comprising 15 trials demonstrated that these agents significantly reduce body weight and improve cardiovascular risk factors, including systolic and diastolic blood pressure, as well as lipid profiles [58]