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Even with safety monitoring systems like the UKs Medicines and Healthcare products Regulatory Agency (MHRA) logging hundreds of reported cases over time, no direct causal relationship has been confirmed
This unexpected result raised the possibility that reduced lag-2 expression, either directly or through the resulting decrease in GLP-1/Notch activity, led to an increase in DTC-AC
Most of the longevity data comes from animal studies, laboratory models, or small observational research from a limited group of investigators
Prevention strategies include weekly medication diaries, dose verification before injection, and never doubling doses for missed injections
J Psychiatry Neurosci 39(1):621
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