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The continuum of aging and age-related diseases: common mechanisms but different rates
Oxidative Medicine and Cellular Longevity 2012:324832. [doi.org]
A well-characterized example of this mechanism is the Keap1Nrf2 signaling axis, illustrated in Fig
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Autophagy can be induced by nutrient deprivation, which activates AMPK (a sensor of energy depletion) and inhibits mammalian target of rapamycin (mTOR, an autophagy suppressor), as well as oxidative stress, hypoxia, exercise, drugs (rapamycin, metformin) and hormones (glucagon)
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