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In addition, the chemokine CCL5, as a key effector molecule of T cells and NK cells, mediates interactions between immune cells, vascular endothelial cells, and smooth muscle cells by binding to receptors such as CCR3 and SDC4, exacerbating vascular occlusion ( 2.2 Metabolic remodeling The occurrence and progression of PH are closely associated with multi-cellular metabolic reprogramming, which collectively drives the pathological process of the disease through abnormal switching of cellular energy metabolic pathways, regulation of key metabolites and signaling pathways, and bidirectional interactions between metabolic disorders and vascular remodeling (Figure 2)

Mechanistic insight into drivers of the NRF2 dependency remains poorly understood

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