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Kakavand H, Crainic O, Lum T, O'Toole SA, Kefford RF, Thompson JF et al

Tirzepatide activates both GLP-1 and GIP receptors, engaging broader appetite-regulation pathways than semaglutide alone

When we eat a donut, its fat, sugar, and starch get absorbed quickly, high up, before reaching the part of our digestive tract where we produce most of the hormone that suppresses our appetite, GLP-1

Within the first several hours post ingestion: the patient is probably asymptomatic but may have some nausea and vomiting

The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue