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The trial in people with T2D included 281 participants (mean age 56 years, 56% women, mean BMI 35.0 kg/m 2 , mean HbA1c 8.3%) treated with lifestyle only and/or metformin, with similar intervention arms to the obesity trial, albeit retatrutide 0.5 mg rather than 1 mg, and dulaglutide 1.5 mg was an additional comparator [46]

These guidelines recommend a combination of aerobic activities, such as walking, cycling, or swimming, with resistance training

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Medicare Supplement insurance is available to those age 65 and older enrolled in Medicare Parts A and B and, in some states, to those under age 65 eligible for Medicare due to disability or End-Stage Renal disease

These comparative studies have been foundational in melanocortin receptor pharmacology research