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We havent really had a new tool in our toolbox from a pharmacotherapy perspective to treat addiction in a long time, said Lembke, noting that some addiction specialists are already prescribing GLP-1s off-label, especially when other treatments have failed

The glucagon receptor (GCGR) is activated by glucagon a hormone produced by pancreatic alpha cells that raises blood glucose and drives hepatic energy mobilisation

This gradual approach minimizes gastrointestinal side effects and allows patients to adjust to the medication

NICE Technology appraisal guidance, March 2023 Liraglutide for managing overweight and obesity

This can and should include taking a medical history and assessing the patients current physical state