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In clinical trials, retatrutide achieved 24.2% weight loss at 48 weeks versus tirzepatide approximately 21% at 72 weeks, suggesting stronger overall appetite and metabolic effects
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Evidence signal Performance research 3 source-backed citations are connected to this page
However, the study shows that 58% of all individuals whose claims were analyzed stop taking their medications before reaching a clinically meaningful level of weight loss, which is defined as at least a 5% reduction in weight from the baseline level
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