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The mechanistic plausibility is strong (NNMT inhibition increases NAD+ without the gastrointestinal side effects of high-dose nicotinamide), and the short-term tolerability profile is excellent, but we mean this sincerely: if you're using this compound for durations beyond what the published trials covered, you are operating in uncharted territory
Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised
Cancer Cell Biology NNMT Inhibition in HeLa Cells (PubMed, 2021) 5-Amino-1MQ Inhibits Cancer Cell Proliferation via NNMT-Dependent Pathways A study published on PubMed investigated the effects of 5-Amino-1MQ (referred to as 5MQ) on HeLa cervical cancer cell proliferation
Biotin (Vitamin B7) supports healthy hair growth, stronger nails, and glowing skin while also playing a key role in converting nutrients into energy
However, whether sustained NNMT inhibition beyond 12 weeks affects liver function in humans is unknown baseline and periodic monitoring of liver enzymes is recommended for use beyond published trial durations
