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These results suggest that regulation of appetite-related hormones may be a critical mechanism associated with SGLT-2i-mediated regulation of body weight and energy
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Evidence synthesis indicated that dual agonists (tirzepatide, mazdutide, and CagriSema) and triple agonists (retatrutide) displayed overall better efficacy than regular GLP-1RA drugs in reducing HbA 1c concentrations, fasting blood glucose concentrations, and body weight (appendix 16)
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