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Acknowledgements We are thankful to the Researchers Supporting Project Number (RSPD2024R751), King Saud University, Riyadh, Saudi Arabia

The medication slows down gastric emptying, which means food moves from your stomach to the intestine at a slower rate, giving you a feeling of fullness for a longer time, and you experience fewer hunger cravings

Patients should not adjust doses of either medication independently

Semaglutide prevented leukocyte adhesion and rolling, as well as astrocyte detachment from the brain vessels, possibly through a mechanism involving inflammatory mediators within the brain [32] (Supplementary Fig

The rate of weight loss with retatrutide was noticeably faster, with substantial reductions appearing earlier in the treatment course