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Glossary ART assisted reproductive technology ATP adenosine triphosphate CAT catalase CPM cyclophosphamide Cyt c cytochrome c DOR diminished ovarian reserve FADD fas-associated death domain GCs granulosa cells GPx glutathione peroxidase GPx3 glutathione peroxidase 3 GSH glutathione GSH-Px glutathione peroxidase GSS glutathione synthetase Gsta4 glutathione transferase 4 H2O2 hydrogen peroxide HIF1 hypoxia-inducible factor 1-alpha HO-1 heme oxygenase-1 IFN- interferon gamma IL-18 interleukin 18 IL-1 interleukin 1 beta iNOS inducible nitric oxide synthase IVM in vitro maturation LPS lipopolysaccharides MDA malondialdehyde Mgst1 microsomal glutathione S-transferase 1 MMP mitochondrial membrane potential MPF maturation promoting factor MTX methotrexate MV Mogroside V NAC N-acetylcysteine NF-B nuclear transcription factor B 3-NPA 3-nitropropionic acid Nrf2 nuclear factor erythroid 2-related factor 2 PA Proanthocyanidin PCOS polycystic ovary syndrome PGC1 peroxisome proliferator-activated receptor gamma coactivator 1- POA postovulatory aging POF primary ovarian failure POI primary ovarian insufficiency POLG polymerase subunit gamma Prdx3 peroxiredoxin 3 ROS reactive oxygen species SIRT1 nicotinamide adenosine dinucleotide-dependent deacetylase sirtuin-1 SODs auperoxide dismutases TAS total antioxidant status TFAM transcription factor a tGSH total glutathione TNF tumor necrosis factor-alpha TNFR2 tumor necrosis factor receptor 2 TOS total oxidant status References 1 AbaisJ
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Gene expression analysis using the Broad Institute Connectivity Map The authors analysed how GHK-Cu affects human gene expression using the Connectivity Map (CMap) a massive database developed at MIT and Harvard that maps how compounds alter gene activity
Common side effects associated with nootropics include: Headaches Nausea Insomnia Anxiety Increased heart rate and blood pressure Additionally, some nootropics can interact with other medications, such as blood thinners, and may not be suitable for individuals with certain medical conditions, including high blood pressure or glaucoma
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