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Gastrointestinal adverse events were the most common, and treatment discontinuations increased with higher doses, reinforcing the importance of careful patient selection and shared decision-making
Compounding pharmacies and investors have brought legal challenges to enjoin the FDA from enforcing the changes to the shortage list, but have so far been unsuccessful
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In the study by Fontcuberta-PiSunyer et al., human fibroblasts were directly reprogrammed using adenoviral vectors delivering NEUROG3, PDX1, and MAFA, followed sequentially by PAX4 and NKX2-2
