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Figure 3: Structure of the pancreas with Islet of Langerhans, credit: BruceBlaus, Wikimedia Knowledge about the pancreas deepened further as a result of research by Ernest Starling and his brother-in-law William Bayllis, two British physiologists at UCL

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Research examining human cardiac samples has revealed several key findings: GLP-1R mRNA transcripts have been consistently detected in all four cardiac chambers from human hearts, at levels approximating those in human pancreas [1] Receptor expression is notably absent in cardiac fibroblasts, coronary artery endothelial cells, and vascular smooth muscle cells according to some studies [1] Human GLP-1R expression appears predominantly in cardiomyocytes, albeit at relatively low levels [2] Interestingly, species differences exist in GLP-1R distribution patterns

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