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& Ookhtens, M

Within cells, creatine is phosphorylated by creatine kinases (CK

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19 Mechanistically, this vesicular cargo acts through the glutamine-fructose-6-phosphate transaminase 1 (GFPT1)-hexosamine biosynthesis pathway and transcriptional regulator BTB and CNC homolog 2 (BACH2)-dependent repression of the SLC7A11-GPX4 axis, thereby lowering the ferroptotic threshold of adjacent cells