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doi: 10.1210/clinem/dgz069 130 FDA Briefing Document, Endocrinologic and Metabolic Drugs Advisory Committee Meeting (EMDA) (2017)

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The presenters noted this was more common in the higher doses of retatrutide and more common in patients already on anti-hypertension medications and tended to resolve after stopping the blood pressure medication or increasing fluid intake

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This suggests that individuals with a higher BMI may need more supplemental vitamin D than leaner individuals and is consistent with previous evidence indicating that obesity may impair formation of active vitamin D