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Bocangel DB, Holzen UV, Chada S, Pataer A, Takada Y, Raju U, Aggarwal BB, Barber GN, Chiao P, Milas L, Hunt KK, Swisher SG

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This phenomenon is clearly observed in the STEP 2 trial of semaglutide (2.4 mg weekly), where a cumulative 33.7% of patients with obesity and T2D reported nausea throughout the duration of the trial ( It has been hypothesized that the deleterious, nauseating effects of GLP-1R agonists and the beneficial, food-intake reducing effects are inextricably linked

muciniphila synthesizes and secretes bioactive components, including surface proteins, secreted proteins, metabolites, and extracellular vesicles, which synergistically regulate oxidative stress via host-microbiome interactions [74]