glp 1 hypothalamus JCI Incretin hormones and the satiation

GLP-1s work by slowing stomach emptying, increasing feelings of fullness, and reducing appetite

Although liraglutide is the most studied GLP-1 agonist in psychiatric patients and is available in a generic form, it requires daily dosing and is less effective than the branded, once-weekly GLP-1 agonists semaglutide and tirzepatide.

In a clinical study involving patients with type 2 diabetes, an almond-based diet with a low-carbohydrate content, which had been previously shown to possess marked prebiotic properties [110, 111], resulted in augmentation of the number of SCFA-producing bacteria species, such as Roseburia , Ruminococcus and Eubacterium , which led to an increase in fasting blood GLP-1 levels and also promoted antidepressive effects after three months [112]

It is important to administer the medication on the same day each week (for weekly formulations) or at the same time each day (for daily formulations) to maintain stable blood levels and optimise efficacy

Actualmente, este grupo de medicamentos presenta problemas de suministro que pueden afectar a la continuidad de los tratamientos en pacientes diabticos tipo 2