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Bibcode:2021ChPap..75.6625A

Published February 12, 2021

Substituting tirzepatide for semaglutide is a theoretical extension of that idea pairing an amylin analog with a more potent dual incretin agonist but it is important to repeat that this specific pairing has not been validated in a dedicated human combination trial

Pairing increased fiber with adequate hydration is essential, as fiber without water can actually slow transit further and worsen symptoms

There are no controlled trials of microinfusion-delivered peptides and growth factors in pregnancy, and the regulatory and clinical default in the absence of safety data is non-intervention