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NICE guidance including Technology Appraisal TA875 (semaglutide 2.4 mg for managing overweight and obesity), Clinical Guideline CG189 (Obesity: identification, assessment and management), and Public Health Guidance PH53 (Weight management: lifestyle services for overweight or obese adults) recommends a structured, tiered approach to weight management

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That means if a dose is gradually increased, then it might help to minimise side effects

Reports suggest a surge in off-label use among non-diabetic individuals driven by online hype

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