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Inside the mitochondrion, malate is oxidized by the MDH2 encoded enzyme of the TCA cycle, producing OAA and NADH

For example, whereas sulphide-oxidising activity is virtually undetectable in nervous system cells, colonocytes display high expression and activity of SOP enzymes, 131,132,133 consistent with the high H 2 S concentrations that result from gut microbial metabolism

Ultimately, the dosing schedule should reflect the studys objectives, timeline, and available resources