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While both are effective, tirzepatide generally edges out semaglutide as the best GLP-1 for weight loss in head-to-head comparisons showing 20-25% greater weight reduction

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74 In one randomized, placebo-controlled, crossover trial that included 24 healthy participants aged 55 years and older who had no major sleep issues, 5 mg melatonin 30 minutes before bedtime in controlled experimental conditions increased sleep efficiency, mainly by increasing stage 2 NREM sleep and slightly shortening awakenings

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