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Cagrilintide's amylin mechanism (different pathway) How cagrilintide works: Amylin receptor agonist Long-acting weekly injection Investigational (not FDA approved) Different receptors than GIP/GLP-1 Amylin pathway effects: Very strong gastric emptying delay (stronger than GLP-1) Central appetite suppression (area postrema) Reduces meal frequency Suppresses glucagon Enhances satiety Cagrilintide monotherapy results: 10-12% average body weight loss Significant GI side effects (stronger gastric slowing) Currently in Phase 3 trials Not yet available pharmaceutically See our cagrilintide weight loss , cagrilintide dosing , and cagrilintide and semaglutide guides

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J.RoseS.MelnykS.JerniganS.BlossomS.PavlivO.et al (2009)