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Important: Microdosing has not been evaluated in large randomized clinical trials

The excretion and reabsorption of uric acid are important processes in uric acid metabolism, with several transport proteins, particularly URAT1, GLUT9, and ABCG2, found in the proximal tubules of the kidneys and intestines, playing a crucial role in the transmembrane transport of large-molecule urate salts and contributing significantly to the balance of serum uric acid

Of the 2,243 remaining articles from the database search, 1,859 could not be accessed through journal paywalls, leaving 384 articles to be individually assessed for eligibility

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