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Studies examining body composition changes during GLP-1 therapy, including the STEP trials (semaglutide) and SURMOUNT-1 (tirzepatide), have demonstrated that approximately 2540% of total weight lost may come from lean body mass, including skeletal muscle, rather than exclusively from fat mass
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these receptors include Toll-like receptors (TLRs), nucleotide-binding domain and leucine-rich repeat containing proteins (NLRs), AIM2-like receptors (ALRs), RIG-I-like receptors (RLRs) and cGAS, which collectively initiate inflammatory and antimicrobial signalling pathways
These are treatments that can be used alongside semaglutide to minimize side effects
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