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Semaglutide and Tirzepatide are injectable medications originally designed to treat Type 2 diabetes

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Metformin-induced upregulation of GLP-1 receptor (GLP-1R) level and protein kinase A (PKA) phosphorylation may contribute to the synergistic protective effects of the combination therapy The vascular protective effects of liraglutide could be improved by metformin, as demonstrated in our in vitro and in vivo studies

Activities of superoxide dismutase (SOD) and catalase are measured spectrophotometrically