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Physiologically, Fe + -bound transferrin (TF) is internalized via transferrin receptor 1 (TFR1), reduced to Fe + and transported by divalent metal transporter 1 (DMT1) into the labile iron pool (LIP) or ferritin ( + to trigger Fenton reaction, ROS production, LPO and ferroptosis

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In some cases, TB-500 may cause temporary feelings of tiredness [12]

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At that timepoint, weight loss had not yet plateaued, suggesting that treatment beyond one year could produce additional benefits