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Franklin ZJ, OHarte FPM, Irwin N (2014) Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice
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10.1016/j.cmet.2019.07.003 118 ZhangA
2017;12:e0175222
A different randomized, double-blind, placebo-controlled clinical trial demonstrated that daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study induced a significant subjective improvement of penile erectile function, as assessed through standardized OLeary questionnaire for ED, although without a significant improvement of penile vascular parameters assessed by basal PDU, in 29 middle-aged/elderly men affected by organic ED of mixed etiology and unknown severity, therefore reporting, in line with the results of the current study, a discrepancy between subjective and objective improvement in erectile function [28]
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