Since the latter are thought to exert their glucose-lowering activity by preventing the degradation and inactivation (with regard to insulinotropic effects) of endogenously released intact, biologically active GLP-1 [9], their pharmacological action should critically depend on availability of the major substrate, GLP-1
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If theres enough money to be made, interest will do the work to get that on-label indication, Fendrick said
Without strong human studies on the exact product, it is difficult to know whether the patch meaningfully changes appetite, weight, or glucose control