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[5] Disruption of these pathways leads to accumulation of homocysteine and methylmalonic acid, metabolic signatures linked to megaloblastic anemia and demyelinating neuropathy

As a result, the imbalance in MET can intensify glycolysis, leading to substantial lactate generation, which, in turn, weakens CTL activity and promotes immune evasion by tumors

25,26,27 We first performed RNA-seq of wild-type PGCs at E9.5 and analyzed the FPKM values of TRIM family genes (Supplementary information, Table S1)

(2023) 11:e0366422

This suggests that GHK-Cu, a copper complex recognized for its healing capacities, might have a role in reducing inflammation and preventing tissue breakdown in models of ischemic wounds, where blood flow restriction potentially causes tissue damage