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Kim YJ, Lee SM, Choi GE, Hwang SH, Kim HH, Lee EY, Chang CL

Driven by the Haber-Weiss and Fenton reactions [Table 2], excess copper ions initially generate hydroxyl radicals, which subsequently convert copper into highly reactive intermediates (peroxyl, hydroperoxyl, and superoxyl species)

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10.1016/s0140-6736(17)31791-9 Lancet 9 KilJ.PierceC.TranH.GuR.LynchE

NLRP3 inhibitors like 16673-34-0, an intermediate substrate free of the cyclohexylurea moiety involved in insulin release, have shown efficacy in preclinical models of myocardial IR (reduced infarct size by ~30% and improved ejection fraction) (112)