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Higher doses produce increased incidence and severity of gastrointestinal symptoms, which explains why clinical protocols use gradual dose escalation starting at 0.25 mg weekly and incrementally increasing every 4 weeks

Sanitize both vials

However, a functional assignment of these residues remains difficult because of the absence of structures with transition-state analogues that allow the discrimination between the glutathione moieties from the GSSR substrate or GSH (Fig

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doi: 10.1084/jem.20090560 53 GaoYWangZJinXWangXTaoYHuangS