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As reimbursement policies become more favorable and generic alternatives enter the market, accessibility to liraglutide and semaglutide is expected to increase, reinforcing their role as cornerstone treatments for metabolic disorders

This integrated approach identified 455 unique metabolite features (Supplementary Tables 1, 2)

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This pattern holds true across essentially all pharmacological and surgical weight loss interventions, reflecting the persistent nature of the metabolic adaptations that favor weight regain