Hydrocarbon-stapled peptides are covalently constrained alpha-helical peptidomimetics, synthesized by substitution of two strategically spaced residues with terminal olefin-containing unnatural amino acids, followed by ring-closing olefin metathesis (RCM) to cyclize the peptide
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Kumarathurai P, Anholm C, Larsen BS, Olsen RH, Madsbad S, Kristiansen O, et al
These drugs have been affecting libido, as Dr Naveed Asif, a GP from London General Practice, explained: From a physical perspective, GLP-1 medications affect smooth muscle activity, which can influence arousability and orgasm due to changes in blood flow to the genital area