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Wang Y, Gao F, Li X, Niu G, Yang Y, Li H et al (2022) Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment
This is where the synergy with antioxidants becomes vital
In the process of glucose oxidation, NADP + is reduced to NADPH (reduced NAD phosphate)
However, the drug is not without drawbacks
Through these mechanisms, SIN helps to maintain the dynamic balance between M1 and M2 macrophages, reduces macrophage chemotaxis and secretion, and inhibits macrophage apoptosis, thereby exerting potent immunosuppressive effects (Figure 4)
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