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TRIM37 deficiency disrupted the binding profile of the TRIM28 repressor complex, leading to increased chromatin accessibility and H3K27ac modification at soma-specific loci and the upregulation of associated genes
(2024) 20:e2309597
These findings highlight the importance of considering cellular heterogeneity in ferroptosis regulation and suggest that targeting ferroptosis in a subpopulation-specific manner may enhance therapeutic precision in OA
This may help manage the intense cardiovascular demands and rapid heart rates associated with dysautonomia and POTS
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