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High levels of amino acid in the blood increases the chance of heart disease, sudden death of brain cells, Dementia, and porous bones.The deficiency of B12 in the body may result in pernicious anemia , low red blood cells in the body, tiredness, breathlessness, unusual fast beating of the heart

Homocysteine can either be remethylated to methionine or metabolized to cysteine through a transsulfuration pathway requiring vitamin B 6

PMID 18709880

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