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If cold sensitivity is severe or persistent beyond month four of treatment, discuss it with your PlexusDx providerit may indicate that your current semaglutide dose or formulation needs adjustment, or that your genetic profile (revealed through the Precision Peptide Genetic Test) suggests a different compound would be better tolerated

** Based on the treatment policy estimand: treatment effect regardless of if patients stayed on treatment or took other weight loss therapies

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The role of compounded formulations in results Not all semaglutide formulations produce identical results on identical timelines, and understanding the differences helps set appropriate expectations for your specific protocol