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Polyneuropathy typically presents gradually, beginning with paresthesia known as burning feet, followed by gait disturbances and variable muscle weakness in the lower limbs (5, 7)

This likely reflects a selection effect , where individuals capable of exercising far above their typical baseline tend to be more physically fit and therefore exhibit lower resting heart rates and higher HRV

It can lead to sleep disruption, which may increase levels of cortisol

Struggle with significant insulin resistance

They argue that while compounding pharmacies play an important role, the production of complex biologics like GLP-1 receptor agonists should be left to manufacturers who can ensure consistent quality and safety