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Suppositories have a few drawbacks

LPA is converted to phosphatidic acid through a reaction with another FA-CoA molecule, catalyzed by acylglycerol-phosphate acyltransferase

Expert opinion on drug safety

If you are experiencing fatigue, our providers will conduct a thorough evaluation, including necessary blood tests, to determine whether B12 deficiency or another underlying condition may be contributing to your symptoms

Safety and Regulation: Since it is not approved by major regulatory bodies like the FDA for any medical use, its presence in blood when administered as a supplement or drug raises questions about safety, efficacy, and legal implications