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But over time, such deficiency may cause anemia, nerve damage, and even problems with memory and reasoning

Depending on the severity of the tear, symptoms, and overall condition, we may recommend non-surgical options such as rest, activity modification, and physical therapy

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Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)

A narrower mechanism usually means fewer off-target signals to interpret